The brown tumor is a presentation of osteitis fibrosa cystica that represents a serious complication of renal osteodystrophy, mainly affecting the hands, feet, and craniofacial region. Secondary hyperparathyroidism is a common complication of chronic kidney failure. A clinical case of a 32-year-old woman with chronic kidney disease dependent on hemodialysis is presented, who was evaluated in 2018 for a palatal and vertebral tumor, later did not attend controls and was reassessed in 2020, where it was evidenced the development of secondary hyperparathyroidism and brown tumor in the calvarium, vertebra at the C7 level, maxilla and mandible, diagnosis confirmed by incisional biopsy together with clinical history, radiographic and laboratory tests that included serum levels of calcium, alkaline phosphatase, parathyroid hormone and phosphorus.