Since the discovery of hyaluronic acid (HA) and its multiple biological functions, it has awakened interest in different areas of medicine, such as ophthalmology, rheumatology and mainly dermatology and cosmetic surgery, among other specialties, with some clinical applications. Among the non-surgical regenerative and reconstructive facial procedures, HA dermal filler is one of the most used nowadays, since it performs a supplementary task in the regeneration and healing of tissues, by providing a structure that facilitates cell growth. The cleft lip and palate (FLAP) are the most prevalent congenital craniofacial defects, where patients with FLAP may present certain lip asymmetries even after surgical treatment with multiple surgeries, which could lead the patient to various psychological disorders. The biological characteristics, the safety and the almost null adverse effects include the HA as an excellent alternative for facial filler helping the aesthetics, functionality and psychological well-being of the patient through a less invasive and non-surgical process. The aim of this article is to present a clinical case with the use of injectable HA to correct the volumetric and aesthetic lip asymmetries produced in the post-surgical rehabilitation of patients with fissures and discusses its use.