Tuberculosis (TB) is a transmissible bacterial disease caused by Mycobacterium tuberculosis. TB is one of the leading causes of death worldwide. Head and neck TB (HNTB) is the term used to describe tuberculous involvement in the head and neck areas. The diagnosis and treatment of HNTB remains a challenge due to the non-specific clinical presentation of the disease and the paucibacillary nature, and many times the requirement for invasive procedures. The case of a patient 16-year-old female attended due to the presence of a mass in the right submandibular region of 4 years of evolution. CT imaging studies with and without contrast, Doppler ultrasound, and laboratory tests are requested. Surgery is planned by the Maxilofacial Surgery team in conjuction with the Head and Neck Surgery team, where it is decided to perform an excisional biopsy with a right cervicotomy approach for diagnostic confirmation of the lesion in the Operating Room (OR) under general anesthesia. Then patient was referred to general medicine for pharmacological management. Tubercu- losis continues to be a global health problem. The route of Mycobacterium tuberculosis to head and neck lymph nodes remains controversial, particularly in patients without pulmonary tuberculosis. The differential diagnosis of cervical tuberculous lymphadenopathy is challenging. There are infectious and non- infectious causes that must be thoroughly studied to rule out differential diagnoses. Multidisciplinary management is essential for the clinical picture to remit completely.