The aim is to assess the clinical studies regarding the reported complications of implant placement with computer-guided surgery in partially/ fully edentulous patients. The PubMed and Google Scholar databases were searched from 2000 to 2020 for pertinent clinical studies written in English. The PRISMA 2020 guidelines were followed. Two examiners conducted the quality assessment according to the methodological quality and synthesis of case series and case reports. At first, a total of 1057 papers were screened and 17 papers finally were included of which, one was the cohort, three were case series and 13 were case reports. Complications and errors of surgical guides were mostly three parts: 6 out of 17 articles reported preoperative complications, 9 articles reported complications during surgery that occurred for the patient or surgeon, and 11 articles reported postoperative complications. Computer-guided implantology is not flawless. So dentists should receive comprehensive training to prevent serious complications. Sufficient mastery to create a correct and accurate position for the implant and observing the important points of anatomical structures such as the alveolar nerve is one of the important points of this technique.